Ashley Holland

Hello! My name is Ashley Holland, and I’m currently a sophomore here at FSU! I am originally from Atlanta, Georgia. I am also a pre-med student, and I hope to go to medical school after I graduate! Here at FSU, I am involved in UROP and plan to continue research after this program as well!

Literature Review – Vascular and Metabolic Dysfunction

Authors: Ashley Holland, Cesar Meza
Student Major: Cell and Molecular Neuroscience
Mentor: Cesar Meza
Mentor’s Department: Department of Nutrition, Food & Exercise Sciences
Mentor’s College: College of Health and Human Sciences
Co-Presenters: Giovanna Cross, Riley Hart, Isabella Eaton


Vascular and metabolic dysfunction both occur in obesity, and increased NADPH oxidative (Nox) activity has emerged as a key event in the development of cardiometabolic diseases. Data from the Hickner laboratory has identified that Nox is a major determinant of vascular complications in people with obesity. There is, however, limited research in humans that integrates the effects of Nox in vascular and metabolic tissues. Cell culture studies have identified Nox as a stimulus of lipolysis, which is the process of breaking down stored triglycerides and releasing them into the bloodstream. The overall goal of this study is to understand if Nox in adipose tissue and the adipose vasculature contribute to elevated blood glucose profiles through heightened rates of lipolysis and subsequent increased gluconeogenesis and hepatic glucose output.

Keywords: vascular, metabolic, NOX, obesity, lipolysis